Given the rapid transmission, high contagion, and high pathogenicity of SARS-CoV-2, it is in dire need of accurate and rapid detection of COVID-19. Travel-related cases were reported in many countries, and the more serious of which are the United States, India, Brazil, and France as reported. Up to April 19, 2021, it has been reported that 1421 million total cases were confirmed positive to COVID-19, and 3 million people were died around the world, including 103,317 confirmed cases and 4856 death tolls in China. Just as SARS-CoV and MERS-CoV, this novel coronavirus can spread across species and between human beings, with a transmission rate ( R 0) of 2.2%, similar to SARS (3%), indicating that just as easy to spread as SARS-CoV. Considering the rare direct contact between bats and humans, the intermediate hosts are still unknown. Compared with the genome of SARS-CoV-2, the genome of the novel virus is 79.5% identical to SARS-CoV, while the homology of the Bat-CoV-RaTG13 gene, from the bat, reaches 96%, indicating that COVID-19 may cross-species barrier and originate in bats. According to the complete genome sequences revealed by scientists of the National Institute of Viral Disease Control and Prevention (IVDC), the pneumonia disease causative agent is SARS-CoV-2, which has been identified as a novel coronavirus classified as a β lineage betacoronaviruses, including MERS-CoV, SARS-CoV, SARS-related coronavirus (SARSr-CoV), etc. Since the end of 2019, an ongoing pandemic referred to as Corona Virus Disease 2019 (COVID-19) was reported via a human-to-human transmission manner.
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